Research HighlightsTowards continuous operation of bioseparation processes
The high operating costs as well as the increased energy consumption of bioprocesses render improvements in their operation vital. In particular there has been an increasing industrial interest to shift biomanufacturing towards continuous operation. To facilitate this we develop advanced computational tools for the optimization and control of such processes. In particular, we look into the development of high-fidelity process models that will provide invaluable insight in the process dynamics and will form a solid basis for the design and development of advanced control strategies. We also consider issues arising from the process complexity and periodicity during operation. |